10k swaps per day is pretty high, especially for the PXA buffer. I'd definitely increase it if you have enough physical memory; the only impact is that it's going to allocated a larger chunk of shared memory, so if you don't have enough physical RAM to absorb the increase without swapping, you're not going to gain much. 500MB is pretty small for the program buffer these days, but that would depend on what modules you're running. I've hardly ever seen this below 1GB lately, and normally in the 1.5 - 2GB range for ERP systems with multiple modules implemented on a single app server.
The rule of thumb I've used is to try to keep at least 10% free (both space and # of entries). From your screen shot it looks like you need to increase the size of the field definition buffer, program buffer, CUA buffer, and export/import buffer.
Rich
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