You can. PowerBuilder major versions are largely compatible with one another. About the only issue is that some of the third party files (e.g., libjcc.dll) are shared, and later versions of PB include later versions of those files that may include additional dependencies. That gets a bit confusing when the docs for the earlier version of PB don't include those new dependencies for deployment.
However, I've gotten to the point that anytime I'm evaluating new software I just put it on a new VirtualBox virtual machine. You don't to worry about uninstalling it later, you just do a refresh on that image.
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