Error: First RFC call failed, config not loaded. Check the System landscape configuration. Exception occured while processing the current request; this exception cannot be handled by the application or framework
I fallow these steps from my side
GO to Business Explorer -------> web Application Designer ---------> give user and password
Click on open Existing Web Template click on execute button i noticed below error.
BEx Web Application
Thanks for suggest this 1903392 note. I solved my issue with the help of this note.