In T-code Va41 Default Item description and Unit of Measurement was Coming, It is coming for first item only , i also checked with SHD0, But there is no Transaction and screen variant is there for Va41.
It's not a standard transaction behavior. Either there is a bug or there is some custom development and you just haven't found it yet. An ABAPer should be able to debug to see where the field value is changing. If after that you still conclude that there is no customization of any kind, send a message to SAP.
As already pointed out, definitely, this should be due to some exit. Take the help of ABAPer and redo the process in debug mode and find out from where, the description and unit of measurement are picking.
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