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A2A Vs B2B

What are all the Major differences between A2A and B2B

In A2A(Inside our Corporate Boundary) and B2B(Outside our Corporate Boundary) we need to have the following for sure

1) Sender and Receiver Adapter

2) Message Mapping (if the source and Target structures are different).

What other differences we can list? In XI whats the different process that we need to take into consideration when we do B2B (File1 to File2) when compared to A2A (File1 to File2) ?

Thanks

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