How you deal with them, depends on what is in them. If the goods issues and goods receipts are not in balance, and the values are material, you should do a WIP calculation and post that. Otherwise you can do nothing.
It also depends on why the order is open - is it still being produced, or is it an old order. Old orders should be closed some or other time, so that they can be excluded from the month-end runs, and later on be archived. Large numbers of open orders can slow down the system during month-end processing.
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